Equine and Porcine Bone Substitutes in Maxillary Sinus Augmentation: A Histological and Immunohistochemical Analysis of VEGF Expression.
Identifieur interne : 000815 ( Main/Exploration ); précédent : 000814; suivant : 000816Equine and Porcine Bone Substitutes in Maxillary Sinus Augmentation: A Histological and Immunohistochemical Analysis of VEGF Expression.
Auteurs : Stefano Tetè [Italie] ; Vincenzo Luca Zizzari ; Raffaele Vinci ; Susi Zara ; Umberto Di Tore ; Marco Manica ; Amelia Cataldi ; Carmen Mortellaro ; Adriano Piattelli ; Enrico GherloneSource :
- The Journal of craniofacial surgery [ 1536-3732 ] ; 2014.
Abstract
The aim of this work was to investigate the morphological structure and the expression of vascular endothelial growth factor (VEGF) after maxillary sinus augmentation through equine and porcine bone substitutes in humans.Ten patients showing edentulous posterior maxilla underwent maxillary sinus augmentation through particulate equine bone substitute and 10 patients through particulate porcine bone substitute. At the moment of implants insertion, 6 months after grafting, bone specimens were withdrawn and processed for morphological and immunohistochemical analyses.Notwithstanding the almost comparable clinical performances of both bone substitutes, histological results showed a better integration when an equine bone substitute was used compared to a porcine one. In particular, evident signs of particles resorption were observed in equine bone substitute group specimens compared to porcine ones. Immunohistochemical analysis showed a statistically significant increase of VEGF expression in equine compared to porcine bone substitute group specimens.These results showed both bone substitutes to achieve comparable clinical performance, indicating their successful use for bone regenerative procedures. However, in the same experimental time, equine group specimens showed evident resorption phenomena, whereas no or little signs of resorption were evident in the porcine group specimens. However, a more rapid and intense vascularization was achieved in equine bone substitute group, as demonstrated by immunohistochemical analysis for VEGF expression. Even if differences in vascularization significantly affect the clinical performance of a heterologous bone substitute, its ability to be resorbed is also very important in influencing long-term integration and long-term predictability of implant-prosthetic rehabilitation in regenerated sites.
DOI: 10.1097/SCS.0000000000000739
PubMed: 24769613
Affiliations:
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At the moment of implants insertion, 6 months after grafting, bone specimens were withdrawn and processed for morphological and immunohistochemical analyses.Notwithstanding the almost comparable clinical performances of both bone substitutes, histological results showed a better integration when an equine bone substitute was used compared to a porcine one. In particular, evident signs of particles resorption were observed in equine bone substitute group specimens compared to porcine ones. Immunohistochemical analysis showed a statistically significant increase of VEGF expression in equine compared to porcine bone substitute group specimens.These results showed both bone substitutes to achieve comparable clinical performance, indicating their successful use for bone regenerative procedures. However, in the same experimental time, equine group specimens showed evident resorption phenomena, whereas no or little signs of resorption were evident in the porcine group specimens. However, a more rapid and intense vascularization was achieved in equine bone substitute group, as demonstrated by immunohistochemical analysis for VEGF expression. Even if differences in vascularization significantly affect the clinical performance of a heterologous bone substitute, its ability to be resorbed is also very important in influencing long-term integration and long-term predictability of implant-prosthetic rehabilitation in regenerated sites.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Piémont</li></region><settlement><li>Turin</li></settlement></list><tree><noCountry><name sortKey="Cataldi, Amelia" sort="Cataldi, Amelia" uniqKey="Cataldi A" first="Amelia" last="Cataldi">Amelia Cataldi</name><name sortKey="Di Tore, Umberto" sort="Di Tore, Umberto" uniqKey="Di Tore U" first="Umberto" last="Di Tore">Umberto Di Tore</name><name sortKey="Gherlone, Enrico" sort="Gherlone, Enrico" uniqKey="Gherlone E" first="Enrico" last="Gherlone">Enrico Gherlone</name><name sortKey="Manica, Marco" sort="Manica, Marco" uniqKey="Manica M" first="Marco" last="Manica">Marco Manica</name><name sortKey="Mortellaro, Carmen" sort="Mortellaro, Carmen" uniqKey="Mortellaro C" first="Carmen" last="Mortellaro">Carmen Mortellaro</name><name sortKey="Piattelli, Adriano" sort="Piattelli, Adriano" uniqKey="Piattelli A" first="Adriano" last="Piattelli">Adriano Piattelli</name><name sortKey="Vinci, Raffaele" sort="Vinci, Raffaele" uniqKey="Vinci R" first="Raffaele" last="Vinci">Raffaele Vinci</name><name sortKey="Zara, Susi" sort="Zara, Susi" uniqKey="Zara S" first="Susi" last="Zara">Susi Zara</name><name sortKey="Zizzari, Vincenzo Luca" sort="Zizzari, Vincenzo Luca" uniqKey="Zizzari V" first="Vincenzo Luca" last="Zizzari">Vincenzo Luca Zizzari</name></noCountry><country name="Italie"><region name="Piémont"><name sortKey="Tete, Stefano" sort="Tete, Stefano" uniqKey="Tete S" first="Stefano" last="Tetè">Stefano Tetè</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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